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Cilia-Associated Oxysterols Activate Smoothened

Twitter summary of a paper I contributed to.

eamon Uncategorized Leave a comment October 29, 2018October 29, 2018 1 Minute

Two new crystal structures of SMO… with serious issues

In which I take a closer look at the “active” structures of the GPCR Smoothened reported in: Huang, P., et al. “Structural Basis of Smoothened Activation in Hedgehog Signaling.” Cell, 2018.

eamon Uncategorized 3 Comments October 21, 2018November 16, 2018 15 Minutes

The Nature paper

Structural biology, Smoothened and an anti-cancer drug.

eamon Uncategorized 2 Comments July 20, 2016October 21, 2018 6 Minutes

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